here is a glimpse of my genetic testing and results… I know can see what supplements I need as well as my ability to withstand stress.
LPL: rs328 =LPL codes for the lipoprotein lipase enzyme that removes lipids (fats) from the blood. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
CC-APOC3, rs5128 = The APOC3 gene encodes a protein called Apolipoprotein C3 that is found in triglyceride and cholesterol-containing particles that circulate in the blood. Apolipoprotein C3 inhibits the breakdown of these fat-rich particles in the blood. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension. This impact was recently updated, click here to read more.
AG: CETP,rs708272 = The CETP gene codes for an enzyme that plays a key role in the metabolism of HDL (“good”) cholesterol. This enzyme has also been suggested to be an independent risk factor for coronary artery disease. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
GG: ACE- rs4341: The ACE gene codes for an enzyme that helps control blood pressure by regulating the volume of fluids in the body. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AG: AGT,rs699: The AGT gene codes for a protein involved in maintaining blood pressure. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
CC: PPARG, rs1801282 = The PPARG gene encodes a protein which is involved in the differentiation of fat cells. It is also involved in the regulation of glucose and fats in the blood. My results: Having two copies of the C allele is associated with decreased insulin sensitivity and increased diabetes risk.
CT: TCF7L2, rs7903146: The TCF7L2 gene encodes a protein that regulates blood sugar. Variants in this gene are thought to influence insulin secretion. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AA: FTO, rs9939609 = The FTO gene is expressed in high levels in metabolically active tissues like heart, kidney and brain. Research has suggested that the FTO gene plays a role in appetite regulation and that it is associated with food intake and sense of fullness. My results: The A allele is associated with increased obesity risk. Being overweight increases risk for insulin resistance and type 2 diabetes.
AG: SLC2A2, rs5400 = The SLC2A2 gene codes for a protein known as “Glucose transporter type 2” or GLUT-2. The GLUT-2 protein facilitates the first step in secretion of the blood-sugar regulating hormone, insulin, from the pancreas. Research has suggested that GLUT-2 is a glucose sensor. It is considered to be important in regulating blood sugar after meals, and is involved in food intake and regulation. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
GG:IL6,rs1800795: The IL6 gene encodes a member of the large family of small proteins called cytokines. The IL-6 protein plays a crucial role in inflammation by increasing the expression of the CRP gene, which in turn participates in the acute phase response to inflammation and infection. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
GT: FADS1,rs174537= The FADS1 gene encodes one of the key enzymes in polyunsaturated fatty acid (PUFA) metabolism. Variants in this gene are associated with varying blood concentrations of omega-3 and omega-6 essential fatty acids. This variant in the FADS1 gene is also associated with cholesterol concentrations. My results: The G allele is associated with increased enzyme efficiency, which can be associated with higher blood levels of a potentially pro-inflammatory omega-6 fatty acid called arachidonic acid. Talk to your coach about whether it would be appropriate to consume more omega-3 fatty ac. The SOD proteins play a major role in the antioxidant defense system by destroying the free radicals that are normally produced within cells and are damaging to biological systems. My results: People with one or two copies of the G allele who do not eat enough fruits and vegetables may be at increased risk of developing disease, including certain cancers. Although it is not possible to quantify the risk or the extent to which the risk can be reduced, you may wish to ensure an adequate intake of antioxidants through diet and/or supplements.
ids to help maintain a healthy balance of fats in your bloodstream.
GG: TNF,rs1800629 =The TNF gene codes for a small pro-inflammatory protein that is secreted by both immune cells and fat cells. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
GT: NOS3: rs1799983 =The NOS3 gene codes for an enzyme called “nitric oxide synthase, endothelial”, also known as eNOS. This enzyme plays a key role in the regulation of blood vessel tone. It also protects the blood vessels by multiple physiological actions.
The T allele is associated with a reduction in nitric oxide availability in the blood vessel wall, and it has been associated with increasing risk for atherosclerosis (hardening of the arteries), high blood pressure, and end-stage kidney disease. While it is not possible to quantify the risk or the extent to which the risk can be reduced, you may wish to ensure that your diet has adequate levels of antioxidants and omega-3 fatty acids, which may help combat the impact of this variant.
GG-SOD2, rs4880: SOD2 codes for one of the three members of the superoxide dismutase (SOD) protein family
CC: PPARG, rs1801282 = The PPARG gene encodes a protein which is involved in the differentiation of fat cells. It is also involved in the regulation of glucose and fats in the blood. My results: Having two copies of the C allele is associated with decreased insulin sensitivity and increased diabetes risk.
CT: TCF7L2, rs7903146: The TCF7L2 gene encodes a protein that regulates blood sugar. Variants in this gene are thought to influence insulin secretion. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AA: FTO, rs9939609 = The FTO gene is expressed in high levels in metabolically active tissues like heart, kidney and brain. Research has suggested that the FTO gene plays a role in appetite regulation and that it is associated with food intake and sense of fullness. My results: The A allele is associated with increased obesity risk. Being overweight increases risk for insulin resistance and type 2 diabetes.
CC, SOD3-rs1799895: The SOD3 gene encodes for EC-SOD, one of the members of the superoxide dismutase (SOD) protein family. The SOD proteins play a major role in the antioxidant defense system by destroying the free radicals that are normally produced within cells and are damaging to biological systems. EC-SOD is especially important for protecting the vascular system from oxidative stress. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
Absent:
GSTM1: GSTM1 codes for a member of the GST enzyme family. GST enzymes are involved in phase 2 detoxification of environmental toxins in many different organs. The GST enzyme coded by GSTM1 is very abundant in the liver. My results: A deletion results in the absence of the enzyme coded by the GSTM1 gene, which may affect the body’s normal detoxification processes. There is an association between absence of this enzyme and increased risk for developing certain cancers, sensitivities to chemicals, and coronary artery disease in smokers. While it is impossible to quantify the extent of risk, or whether the risk can be prevented, you may wish to avoid unnecessary exposure to toxins and eat a diet rich in antioxidants. Increasing intake of cruciferous and allium vegetables will support the glutathione pathway by increasing the activity of other GST enzymes.
Present:
GSTT1: GSTT1 codes for a member of the GST enzyme family. GST enzymes are involved in phase 2 detoxification of internal and environmental toxins in many different organs. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AG, GSTP1, rs1695: GSTP1 codes for a member of the GST enzyme family. GST enzymes are involved in phase 2 detoxification of environmental toxins in many different organs. The GST enzyme coded by GSTP1 is most abundant in the lungs where it plays a role in the detoxification of airborne pollutants. My results: The G allele is associated with decreased activity of the enzyme coded by the GSTP1 gene. This impact is more pronounced if there are 2 copies of the G allele. Decreased activity of the GSTP1 enzyme is associated with the development of diseases influenced by oxidative stress (e.g. heart disease, cancer, neurological disease). While it is not possible to quantify the risk, or the extent to which the risk can be reduced, eating a diet rich in cruciferous and allium vegetables will increase the activity of other GST enzymes which may help lower your risk in this area.
AG, CYP1A1, rs4646903: The CYP1A1 gene encodes an enzyme involved in phase 1 detoxification. This enzyme converts a variety of internal and environmental toxins to reactive molecules that will be recognized by the phase 2 detoxification enzymes. If not eliminated, reactive molecules can contribute to the development and growth of cancer, especially in smokers. My results: The G allele has been associated with increased CYP1A1 enzyme activity, which may result in increased DNA damage. While it is not possible to quantify the extent of risk, or whether risk can be prevented, you may wish to avoid unnecessary exposure to dietary and environmental toxins and avoid smoking of any kind.
TT, CYP1A1,rs1048943: The CYP1A1 gene encodes an enzyme involved in phase 1 detoxification. This enzyme converts a variety of internal and environmental toxins to reactive molecules that will be recognized by the phase 2 detoxification enzymes. If not eliminated, reactive molecules can contribute to the development and growth of cancer, especially in smokers. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AG, COMT, rs4680: The COMT gene codes for a protein that is involved in detoxification. In the brain, this protein is involved in the breakdown of certain neurotransmitters, and levels of the protein have been related to both emotional and cognitive functioning. In other tissues, COMT protein participates in the detoxification process of certain hormones, in particular estrogens. My results: The A allele has been associated with a significant reduction in activity of the COMT enzyme, which can impact the detoxification process of neurotransmitters in the brain and hormones in other tissues. Some studies have associated this variant with increased risk for anxiety or anxiety-related traits, especially in women. People with one or two copies of the A allele may have more difficulty handling stressful situations, or have greater stress hormone increases under stressful circumstances. Incorporating regular stress management practice may help reduce chronic stress. In addition to its effect on stress, reduced COMT activity may increase the risk for developing estrogen-related cancer. Diet and other lifestyle choices are known to influence risks for cancer. Talk to your coach about these lifestyle strategies.
GG, MTRR, rs1801394: The MTRR gene encodes an enzyme that plays a crucial role in the metabolism of homocysteine by regenerating vitamin B12 to its active form. My results: Research studies have associated the GG genotype with increased risk of premature coronary artery disease in individuals with vitamin B12 levels that are low. You should discuss with your coach ways to ensure adequate dietary intake of folate, vitamin B12 and vitamin B6.
AG, MTHFR, rs1801133, C677T: The MTHFR gene codes for a key enzyme involved in the metabolism of the B vitamin folate. Folate levels influence blood levels of homocysteine, which has been associated with cardiovascular risk and depression. My results: The A allele is associated with lower activity of the MTHFR enzyme. This reduced enzyme activity can result in lower folate levels and increased homocysteine, which may be associated with risk for heart disease and depression. Individuals with one or two copies of the A allele may have increased needs for dietary folate and vitamins B2, B6 and B12 to help maintain optimal homocysteine levels.
TT, MTHFR, rs1801131, A1298C: The MTHFR gene codes for a key enzyme involved in the metabolism of the B vitamin folate. Folate levels influence blood levels of homocysteine, which has been associated with cardiovascular risk and depression. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AA, MTR, rs1805087: The MTR gene codes for methionine synthase, an enzyme involved in the metabolism of homocysteine. Homocysteine has been associated with the risk of developing heart disease and depression. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
GG, CBS, rs234706: CBS codes for an enzyme that helps regulate homocysteine levels. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
GG, VDR, rs2228570: The VDR gene codes for the vitamin D3 receptor. VDR accounts for a significant amount of the genetic influence on bone density, since it plays an important role in calcium regulation, bone cell growth and differentiation, and intestinal calcium absorption. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AA, VDR, rs731236: The VDR gene codes for the vitamin D3 receptor. VDR accounts for a significant amount of the genetic influence on bone density, since it plays an important role in calcium regulation, bone cell growth and differentiation, and intestinal calcium absorption. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
CC, VDR, rs1544410: The VDR gene codes for the vitamin D3 receptor. VDR accounts for a significant amount of the genetic influence on bone density, since it plays an important role in calcium regulation, bone cell growth and differentiation, and intestinal calcium absorption. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
CC, COL1A1, rs1800012: COL1A1 codes for a protein, Collagen alpha-1(I) chain I, which is needed to make type I collagen. Collagens are the most abundant proteins in our body. They provide strength and support to many tissues including bone, cartilage, skin, and tendon. Type I collagen is the most abundant form of collagen and the major protein of bone. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension.
AA, Caffeine Sensitivity, rs762551, CYP1A2 encodes an enzyme that is involved in the metabolism of caffeine. Variants in this gene can impact how individuals respond to caffeine in coffee, tea, or other beverages. My results: Individuals with the AA genotype are fast metabolizers of caffeine.
AA, Lactose Intolerance,rs4988235: Reduced ability to digest lactose, a sugar common in dairy products, can be due to decreasing levels of the digestive enzyme called “lactase”. The genetic variant reported here is located near the LCT gene that codes for this digestive enzyme and can influence how much of the enzyme is made. My results: You have a genotype which is not known to have an effect on biomarkers for this health dimension. The impact of this genotype in non-European populations has been less well studied and additional variants may affect the expression of the LCT gene. rs1800562:AG and rs1799945:CC, HFE: Hemochromatosis-The HFE gene encodes the hereditary hemochromatosis protein, which is involved in sensing the amount of iron in the body. This protein plays an important role in how the body regulates iron absorption and storage. The two HFE variants tested here are the variants most commonly found in people with iron overload (hemochromatosis). Note that there are other less common variants that can also cause iron overload that are not included in this report. My results: you have a genotype which is not known to have an effect on biomarkers for this health dimension.
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Debbie Potts
